Another proud moment for people of Seemanchal and entire scientific fraternity, as Kishanganj born Scientist Mumtaz Naiyer has another publication in his kitty. Recently his paper on the topic "A Peptide Antagonist Disrupts NK Cell Inhibitory Synapse Formation" is published in world's one of the most coveted scientific journal "The Journal of Immunology". Mumtaz Naiyer, one of the co-author of the paper is highly delighted over his achievement. Naiyer said this is not the end of road for him, he is already working in some other topics and expecting more findings / publications in the field of Immunology.
http://www.ncbi.nlm.nih.gov/pubmed/23382564
Below is the abstract of the finding:
A Peptide Antagonist Disrupts NK Cell Inhibitory Synapse Formation.
Source
Division of Medicine, Imperial College London, London SW7 2AZ, United Kingdom;
Abstract
Productive engagement of MHC class I by inhibitory NK cell receptors depends on the peptide bound by the MHC class I molecule. Peptide:MHC complexes that bind weakly to killer cell Ig-like receptors (KIRs) can antagonize the inhibition mediated by high-affinity peptide:MHC complexes and cause NK cell activation. We show that low-affinity peptide:MHC complexes stall inhibitory signaling at the step of Src homology protein tyrosine phosphatase 1 recruitment and do not go on to form the KIR microclusters induced by high-affinity peptide:MHC, which are associated with Vav dephosphorylation and downstream signaling. Furthermore, the low-affinity peptide:MHC complexes prevented the formation of KIR microclusters by high-affinity peptide:MHC. Thus, peptide antagonism of NK cells is an active phenomenon of inhibitory synapse disruption.
- PMID:
- 23382564
- [PubMed - as supplied by publisher]
